Efficacy comparison of intraperitoneal anaesthesia and post-operative analgesia regimens in laboratory rats

Introduction Effective and safe anesthesia for rodents has long been a leading concern among biomedical researchers. Intraperitoneal injection constitutes an alternative to inhalant anesthesia. Purpose The aim of this study was identify safe, reliable, effective postoperative analgesia protocol laboratory rats exposed painful procedures. Material methods Twenty-seven female Wistar in ongoing that required surgery were randomized into groups three different intraperitoneal protocols regimens. (1) medetomidine + ketamine (MK), (2) xylacine (KX), (3) fentanyl (FM). Three equally distributed the groups: local mepivacaine oral ibuprofen (MI), tramadol (TI), (TTI). A core assigned measure (0-3) (0-2) effectiveness; lower score, more treatment. Results mean MK score 0.44 versus 2.00 FM 2.33 KX. Mean on first day TTI (4.66) TI (9.13), MI (10.14). 48 hours after (3.4), (6.71), (9.5). These differences statistically significant. Conclusion shown be method regimen is strongly recommended light these results.